Modification by vasodilator agents of reoxygention- and calcium- induced contractions in isolated dog cerebral arteries.
نویسندگان
چکیده
منابع مشابه
Endothelial modulation of contractions caused by oxyhemoglobin and NG-nitro-L-arginine in isolated dog and monkey cerebral arteries.
BACKGROUND AND PURPOSE Oxyhemoglobin is a key substance in provoking cerebral vasospasm and a scavenger of nitric oxide. The present study was designed to determine whether suppression of the action of endothelium-derived nitric oxide is involved in oxyhemoglobin-induced cerebroarterial contraction. METHODS Dog and monkey cerebral artery strips with and without endothelium were immersed for i...
متن کاملPharmacological comparison of isolated monkey and dog cerebral arteries.
Pharmacological differences between canine and monkey basilar arteries were studied in vitro. The constrictor response of canine basilar artery to either norepinephrine or an alpha 1-adrenoceptor agonist phenylephrine was partly inhibited by an alpha 2-adrenoceptor antagonist yohimbine but not by an alpha 1-adrenoceptor antagonist prazosin. The contraction elicited by an alpha 2-adrenoceptor ag...
متن کاملCalcium independent contraction induced by iodoacetic acid in isolated cerebral arteries.
In helically-cut strips of cerebral arteries isolated from dogs and monkeys, the addition of 1 mM iodoacetic acid (IAA) produced contractions during an early period (5 to 10 min) and also a prolonged exposure (50 to 70 min). The early contraction was abolished by exposure to Ca++-free media containing EGTA, and significantly attenuated by treatment with procaine or dantrolene. Verapamil, lidoca...
متن کاملCalcium Independent Contraction Induced by Iodoacetic Acid in Isolated Cerebral Arteries
In helically-cut strips of cerebral arteries isolated from dogs and monkeys, the addition of 1 mM iodoacetic acid (IAA) produced contractions during an early period (5 to 10 min) and also a prolonged exposure (50 to 70 min). The early contraction was abolished by exposure to Ca -free media containing EGTA, and significantly attenuated by treatment with procaine or dantrolene. Verapamil, lidocai...
متن کاملCalcium Independent Contraction Induced by Iodoacetic Acid in Isolated Cerebral Arteries
In helically-cut strips of cerebral arteries isolated from dogs and monkeys, the addition of 1 mM iodoacetic acid (IAA) produced contractions during an early period (5 to 10 min) and also a prolonged exposure (50 to 70 min). The early contraction was abolished by exposure to Ca -free media containing EGTA, and significantly attenuated by treatment with procaine or dantrolene. Verapamil, lidocai...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1989
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)56079-6